To analyze the curative effect of modified Yupingfeng Powder combined with seretide inhalation on patients with stable chronic obstructive pulmonary disease(COPD).Methods:A total of 86 patients with stable COPD treated in Qionghai Hospital of Traditional Chinese Medicine from March 2020 to July 2021 were enrolled.According to the simple randomization method，they were divided into control group(n=43) and observation group(n=43).The control group received seretide inhalation，while the observation group was treated with modified Yupingfeng Powder on the basis of the control group.After treatment lasted for 12 weeks，the clinical curative effect and adverse reactions of the two groups were compared.The traditional Chinese medicine(TCM) syndrome scores，peak expiratory flow(PEF)，forced expiratory volume in one second(FEV1)，forced vital capacity(FVC)，FEV1/FVC，airway wall thickness，airway medial-lateral diameter，airway lumen area，levels of CD4+，CD3+ and CD8+，CD4+/CD8+ in peripheral blood and levels of serum matrix metalloproteinase-2(MMP-2)，MMP-3，MMP-9，tissue inhibitor of metalloproteinase(TIMP) 1，TIMP2，interleukin-6(IL-6)，C-reactive protein(CRP) and procalcitonin(PCT) before and after treatment were compared between the two groups.Results:The total response rate of observation group was higher than that of control group(P<0.05).After treatment，the TCM syndrome scores，levels of serum MMP-2，MMP-3，MMP-9，CD8+，IL-6，PCT and CRP，airway wall thickness and airway lumen area in observation group were lower than those in control group，while the levels of FEV1，FVC，FEV1/FVC，TIMP-1，TIMP-2，CD4+，CD3+，CD4+/CD8+ and airway medial-lateral diameter were higher than those in control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Modified Yupingfeng Powder combined with seretide inhalation has significant curative effect on patients with stable COPD，which can enhance immune function，reduce inflammatory response，improve pulmonary function and inhibit airway remodeling.