To observe the effect of Fuzheng Quxie Yangyin Decoction supplemented with chemotherapy in the treatment of advanced non-small cell lung cancer(NSCLC) of qi-yin deficiency.Methods:A total of 120 patients with advanced NSCLC who were treated in the Maanshan General Hospital of Ranger-Duree Healthcare between January 2020 and September 2021 were selected and divided into control group(60 cases，docetaxel+cisplatin chemotherapy) and observation group(60 cases，Fuzheng Quxie Yangyin Decoction on the basis of control group) according to the random number table.The short-term efficacy，traditional Chinese medicine(TCM) symptom scores，tumor markers [serum carbohydrate antigen 125(CA125)，cytokeratin fragment antigen 21-1(CYFRA21-1)，carcinoembryonic antigen(CEA)]，immune function [proportions of natural killer cell(NK)，cytotoxic T cell(Tc) and regulatory T cell(TreGs)]，quality of life [Karnofsky Performance Status Scale(KPS) score]，adverse reactions，1-year progression-free survival time，progression-free survival rate and 1-year overall survival rate were compared between the two groups.Results:There were no differences in the disease control rate，1-year progression-free survival time，progression-free survival rate and 1-year overall survival rate between the two groups(P>0.05).After treatment，differences were found in the TCM symptom scores，tumor markers(CA125，CYFRA21-1，CEA)，immune function(proportions of NK，Tc and Treg) and KPS score between observation group and control group(P<0.05).The incidence of adverse reactions(gastrointestinal reactions，bone marrow suppression，abnormal liver function) in observation were lower than those in control group(P<0.05).Conclusion:Fuzheng Quxie Yangyin Decoction combined with chemotherapy can relieve the clinical symptoms，reduce tumor markers，improve the immune function，and lower adverse reactions in the treatment of patients with advanced NSCLC of qi-yin deficiency.