To conduct a visual analysis of literature related to Compound oleum lithospermi based on CiteSpace，and explore the research hotspots and application scopes.Methods:China National Knowledge Infrastructure(CNKI)，Chinese Citation Database(CCD) and Chinese Science Citation Database(CSPD) and China Biology Medicine(CBM) were searched for relevant literature on Compound oleum lithospermi.After deduplication，Excel and CiteSpace were used to analyze the annual publication volume，region，authors，keywords and keyword clusters，and draw a visualized graph.Results:A total of 826 articles were included，involving 30 regions，381 authors，315 keywords，and 10 keyword clusters.The annual total number of publications and various databases have developed in a three-stage manner，with Shandong publishing the most research on Compound oleum lithospermi and forming a team of authors with Li Yuanwen and Xiao Fei as the cores.Modern research focused on clinical diseases treated by Compound oleum lithospermi，and there were some pharmacological and basic research.Conclusion:The research on Compound oleum lithospermi has a long history and extensive content，where a multi-region and multi-team co-development form has been developed，involving multiple fields such as skin，tumors，anorectal diseases，gynecology and pediatrics and various traditional Chinese medicine(TCM) preparations such as TCM gauze strips，applications，scrubbing，nasal drops and lavage.However，there is a lack of regional co-operation and a small number of core author groups，and phenomena such as off-label drug use without basic research support occurred，which should be improved in the future.