To explore the clinical efficacy of modified Dahuang Mudan decoction in the treatment of hyperuricemia in patients with chronic kidney disease(CKD).Methods:Retrospective analysis was performed，42 cases of hyperuricemia with CKD treated with allopurinol tablets in Qinhuangdao Traditional Chinese Medicine Hospital from October 2019 to June 2022 were included as the control group; 46 cases of hyperuricemia with CKD who received the treatment of modified Dahuang Mudan Decoction combined with allopurinol tablets in the same period were included as the observation group，and they were both treated for 8 weeks.The 24-hour urine protein quantification，24-hour urine uric acid level，clinical efficacy，renal function indicators such as serum creatinine(SCr)，blood urea nitrogen(BUN)，glomerular filtration rate(GFR)，uric acid(UA)，traditional Chinese medicine syndrome score，and incidence of adverse reactions between the two groups were compared.Results:The total effective rates of the observation group and the control group were 91.30%(42 cases/46 cases) and 66.66%(28 cases/42 cases)，respectively.The renal function indicator SCr were(98.21±14.01) μmol/L and(121.52±29.14) μmol/L，respectively; BUN were(7.56±0.63) mmol/L and(9.24±0.98) mmol/L，respectively; serum UA were(681.43±106.73) μmol/L and(549.63±87.49) μmol/L，respectively; GFR were(28.97±9.23) mL/(min·1.732) and(24.56±8.44) mL/(min·1.732)，respectively，and the difference was statistically significant(P<0.05).The uric acid metabolism indicator 24-hour urine protein quantifications were(1.01±0.87) g and(1.94±1.12) g，respectively; 24-hour uric acid levels were(398.31±32.47) μmol/L，(456.32±40.58) μmol/L，respectively，and the difference was statistically significant(P<0.05).TNF-α levels were(45.27±5.93) μg/L and(88.62±8.71) μg/L，respectively; IL-6 levels were(41.73±6.21) ng/L and(82.56±8.98) ng/L，respectively; CRP levels were(7.97±0.38) mg/L and(14.22±1.89) mg/L，respectively，and the difference was statistically significant(P<0.05).The traditional Chinese medicine(TCM) symptom scores of the two groups were both improved，and that of the observation group was lower than that of the control group; the differences were both statistically significant(P<0.05).There were no adverse drug reactions in the observation group and the control group.Conclusion:The treatment of hyperuricemia in patients with CKD with modified Dahuang Mudan Decoction combined with allopurinol tablets is more effective and safe than that with allopurinol tablets alone.