To summarize the experience of Professor LI Kanyin，an academic instructor of the second batch of famous traditional Chinese medicine(TCM) veterans，in the treatment of knee osteoarthritis，and to provide ideas and methods for the clinical treatment of knee osteoarthritis with TCM.Methods:The medical records of knee osteoarthritis in the outpatient clinic of Professor LI that met the inclusion criteria were collected，and the syndrome type，property，flavor，meridian tropism，medication rule and dosage of medicinal materials were analyzed using the relevant functions of data analysis software.Results:A total of 115 prescriptions were screened，involving 108 medicinal materials.The symptom type，frequency of usage，property，flavor，meridian tropism，medication rule and dosage of the medicinal materials were determined，and four syndrome types were obtained.There were 14 medicinal materials with a frequency of usage of more than 40，and they were mainly warm，moderate and cold，with bitter，sweet and pungent properties and mostly acting on the liver，spleen and kidney.Conclusion:By summarizing Professor LI's experience in the treatment of knee osteoarthritis，a self-organized prescription was obtained，which consists of Caulis Spatholobi，Rhizoma Corydalis，Radix Achyranthis Bidentatae，Radix Astragali，and Radix Et Rhizoma Glycyrrhizae.This paper provides ideas and methods for the clinical treatment of knee osteoarthritis with TCM.