中药干预椎间盘退变治疗腰椎间盘突出症作用机制研究进展
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国家重点研发计划项目(2021YFC1712800,2021YFC1712805)


Research Progress in the Mechanisms of Chinese Medicines in the Treatment of Lumbar Disc Herniation due to Intervertebral Disc Degeneration
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    摘要:

    腰椎间盘突出症(LDH)是一种常见的骨科疾病。椎间盘退变是其主要的病理基础,椎间盘生物学活性是影响椎间盘退变程度的重要指标,椎间盘细胞受病理因素影响,会加快衰老,出现细胞代谢障碍,导致细胞内环境稳态破坏,使其生物学活性降低,进一步导致了椎间盘退变的发生。目前现代医学对于LDH的治疗主要集中在手术治疗和非甾体抗炎药等,但是手术创伤较大、非甾体抗炎药较大的不良反应等影响了这类手段的临床疗效。现代基础研究证实,中药(单味药/复方)在治疗疾病过程中具有多成分、多通路、多靶点的特点,能够有效提高椎间盘细胞生物学活性,降低应激反应,抑制细胞凋亡,促进细胞自噬。主要能通过抗炎镇痛、改善微循环、调节免疫功能、促进软骨再生和调节神经系统功能等作用机制来改善LDH的临床症状,在LDH的治疗方面具有独特优势。

    Abstract:

    Lumbar disc herniation(LDH) is a common orthopedic disease,with the main pathological basis of intervertebral disc degeneration,the degree of which can be reflected by the biological activity of intervertebral discs.Influenced by pathological factors,intervertebral disc cells can undergo accelerated aging,metabolic disorders,and dyshomeostasis of the intracellular environment,which lead to a decrease in their biological activity and further the occurrence of intervertebral disc degeneration.Currently,LDH is mainly treated with surgery and non-steroidal anti-inflammatory drugs.However,the surgical trauma and the side effects of the drugs have affected the clinical efficacy of these methods.Modern basic research has confirmed that Chinese medicines(single/compound) can treat LDH via multiple components,pathways,and targets.They can improve the biological activity,reduce stress response,inhibit the apoptosis,and promote the autophagy of intervertebral disc cells.Specifically,they can reduce inflammation,relieve pain,improve microcirculation,modulate the immune function,promote cartilage regeneration,and regulate the nervous system function to mitigate the clinical symptoms of LDH,demonstrating unique advantages in the treatment of LDH.

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韩涛,于杰,金哲峰,展嘉文,陈明,朱立国.中药干预椎间盘退变治疗腰椎间盘突出症作用机制研究进展[J].世界中医药,2023,(21).

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  • 收稿日期:2023-08-01
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  • 在线发布日期: 2023-12-29
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