To evaluate the clinical efficacy and safety of Lanqin oral liquid alone or combined with Western medicine in the treatment of hand，foot and mouth disease in children.Methods:China National Knowledge Infrastructure(CNKI)，China Science Periodical Database(CSPD)，Chinese Citation Database(CCD)，SinMed，PubMed，Web of Science，EMbase，and Cochrane Library were searched for the randomized controlled trials of Lanqin oral liquid alone or combined with Western medicine in the treatment of hand，foot and mouth disease in children.A meta-analysis was performed on the final included articles.Results:A total of 45 articles were included，involving 5 374 cases.The studies of high quality，medium quality，and low quality accounted for 22.2%，62.2%，and 15.6%，respectively，which indicated overall low quality.The results of meta-analysis showed that Lanqin oral liquid combined with ribavirin outperformed ribavirin(RR=1.22，95%CI of 1.19 to 1.26，P<0.05)，and the total response rate of Lanqin oral liquid was higher than that of ribavirin(RR=1.15，95%CI of 1.05 to 1.26，P<0.05).There was no significant difference in the safety(RR=1.20，95%CI of 0.84 to 1.70，P>0.05).Conclusion:Lanqin oral liquid alone or combined with Western medicine has a good clinical effect on hand，foot and mouth disease in children.However，due to the small number of included articles，more evidence remains to be explored.