Coronary heart disease(CHD) is a common chronic disease，posing serious effects on human health and quality of life.As the recognition of traditional Chinese medicine(TCM) is improving，integrated Chinese and Western medicine has become an acceptable method to treat diseases.Nutrient and defense have a close relationship with the heart，and their transformation and transport are inseparable from the spleen.According to the TCM theory，spleen deficiency and dysfunction in transportation lead to the imbalance of nutrient and defense，generation of turbid phlegm，combined phlegm and stasis，and finally heart blood stasis and obstruction.Or the deficiency of nutrient and defense injures qi，blood，yin，and yang of the heart，which can all lead to CHD.TCM serves as a potential therapy for atherosclerotic disease due to its advantages of syndrome differentiation and treatment，mild adverse reactions，long-lasting effects，overall regulation，and no obvious drug dependence.Therefore，harmonizing nutrient and defense and improving their functions from the spleen can prevent and treat CHD.