Colorectal cancer(CRC) is one of the common malignant tumors.Currently，radiotherapy or chemotherapy is the main treatment scheme，which can alleviate patients' symptoms to a certain extent，but the adverse effects during the treatment process seriously affect the efficacy of the treatment.Traditional Chinese medicine(TCM) is a complementary alternative therapy for the prevention and treatment of CRC，which has the advantages of precise efficacy and high safety.Starting from the pathogenesis of intestinal cancer，this paper systematically summarized the possible targets of TCM in the prevention and treatment of CRC from three aspects：gene mutation，abnormal regulation of signaling pathways，and inflammatory microenvironment，and it found the main targets such as Wnt/β-catenin，AMPK，Stat3 gene，MAPK，and P53 gene，so as to further provide ideas and clues for the prevention and treatment of intestinal cancer in clinical TCM and the development of effective drugs.