To establish high performance liquid chromatography(HPLC) fingerprint of Bushen Jiangu Capsule，and to conduct principal component analysis.Methods:The HPLC was performed on a Thermo-Hypersil GOLDTM-C18(250 mm×4.6 mm×5 μm) with mobile phase of acetonitrile-0.2% formic acid solution(gradient elution) at a flow rate of 1.0 mL/min.The detection wavelength was 235 nm，and column temperature was 30 ℃.The simple injection was 10 μL.According to the HPLC fingerprints of 15 batches of samples，the similarity was evaluated and common peaks was determined by the Similarity Evaluation System for Chromatographic Fingerprint of Traditional Chinese Medicine(Version 2012).Principal component analysis was conducted using Minitab 17.0.Results:There were 13 common peaks in the HPLC fingerprints and three were identified：morroniside，loganin and icariin.The similarities of the 15 batches of samples were all greater than 0.9，and there was good similarity between them.Through principal component analysis，two principal components were obtained with the accumulative contribution rate of 92.3%.It was indicated that the content change of components corresponding to common peaks 1，2，4，6，8，and 13 in the samples was an important reason for the quality difference of the samples，especially common peak 13.Conclusion:The established HPLC fingerprint and the principal component analysis facilitate the quality evaluation of Bushen Jiangu Capsule.