To investigate the anti-inflammatory and analgesic effects of Ruhe Sanjie Tablet.Methods:Cotton pellet-induced granuloma formation of Sprague Dawley(SD) rats and the increase in capillary permeability of mice induced by xylene were used to observe the anti-inflammatory effect of Ruhe Sanjie Tablet.The acetic acid writhing experiment in mice was established to observe the analgesic effect of the prescription.Results:The low-，medium-and high-dose Ruhe Sanjie Tablet inhibited the proliferation of rat granulation tissue，and there were differences compared with the blank control group(all P<0.05).The inhibition rates of the three doses were 30.0%，47.4% and 53.6%，respectively，showing a dose-effect relationship.Ruhe Sanjie Tablet at low，medium and high doses reduced the capillary permeability of mice，and the optical density(OD) was lower than that in the blank control group(all P<0.001).The inhibition rates of capillary permeability were 47.6%，55.0% and 65.2%，respectively，with a dose-effect relationship.Ruhe Sanjie Tablet at each dose lowered the number of writhing induced by acetic acid in mice(P<0.001)，and the analgesic inhibition rates at low，medium and high dose were 34.2%，42.0% and 51.5%，respectively，presenting a dose-effect relationship.Conclusion:Pharmacological studies of Ruhe Sanjie Tablet indicates that it has anti-inflammatory and analgesic effects.