Diabetic osteoporosis in western medicine is characterized by abnormal physiological structure and metabolic function of bone tissue under a hyperglycemic state，including prolonged hyperglycemia，vascular damage and blood circulation dysfunction，lipid metabolism abnormalities and hormonal imbalances.Combined with Professor WU Yiling's theory of “endocrine dysfunction in Qi-collateral pathology and microcirculation disorders in vascular-collateral pathology” in traditional Chinese medicine(TCM)，the basic TCM pathogenesis of diabetic osteoporosis can be summarized as spleen and kidney deficiency，obstruction of collaterals，bone-collaterals malnourishment，eventually leading to the occurrence and development of the disease.