To explore the pharmacokinetic characteristics of the full compatibility of tetrahydropalmatine without sinapis alba in the subcutaneous administration of the “Fei Shu” acupoint in a model rabbit and investigate the correlation between pharmacokinetics-pharmacodynamics(PK-PD) according to the principle of “treating winter disease in summer”.Methods:Bronchial asthma model rabbits were randomly divided into yanhusuo alone group，sinapis alba absence group，and full prescription group.Microdialysis technique was used to collect subcutaneous dialysate at the “Fei Shu” acupoint for 14 hours.Liquid chromatography mass spectrometry(LCMS) was employed to detect the concentration of the main component tetrahydropalmatine which is the sovereign medicine in a prescription，obtaining pharmacokinetic parameters.Enzyme-linked immunosorbent assay(ELISA) was performed to detect the IgE level in the serum of model animals at corresponding time points，obtaining pharmacodynamic parameters.PK-PD model fitting was conducted for pharmacokinetic and pharmacodynamic parameters.Results:After compatibility of sinapis alba，the peak concentration(Cmax)，the area under the curve(AUC0-t) and the mean retention time(MRT0-t) significantly increased(P<0.01，P<0.01，P<0.05) and the time to reach peak concentration(Tmax) was earlier(P<0.01).The three-dimensional “concentration-time-effect ” curve showed when sinapis alba was compatible，the drug effect appeared faster，disappeared more slowly，and the onset time was later than the peak concentration，indicating a certain lag.Conclusion:The pharmacokinetic parameters and PK-PD model results suggest that the compatibility of sinapis alba may change the subcutaneous distribution of the main component，tetrahydropalmatine，at the acupoint after administration.This promotes the rapid absorption of effective components of the sovereign drug and prolongs the residence time，playing a ‘dual’ role as the principal drug and improving the distribution of other drugs in the prescription.