Based on data mining technology，this research explored the medication patterns for stroke in Yixue Zhongzhong Canxilu from the perspectives of the support degree single herbs，confidence level of multi-herb combinations and the Euclidean distance.The goal was to uncover medication rules，reveal the patterns of prescribed formulas，and expand the potential clinical applications.Methods:Excel software was used to establish the three databases of stroke in Yixue Zhongzhong Canxilu：stroke formulas，medicinal herbs，and decoction methods.Standardized processing rules were formulated，and measurement indicators were introduced to handle the data.The support degree of drugs was calculated，and high-support drugs and drug pairs were selected for confidence calculation.The Euclidean distance was computed using SPSS software.Results:There are a total of 31 formulas for stroke in Yixue Zhongzhong Canxilu，utilizing 65 different medicinal herbs with a total frequency of 259 occurrences.Among them，neutral and cold-natured herbs each account for 25%; herbs related to the liver and spleen meridians each make up 19%; Bitter-tasting herbs constitute 40%; sweet-tasting herbs make up 39%.The top three herbs in terms of frequency are respectively radix paeoniae alba，achyranthes bidentata，and ochre.In the high-frequency items，there are 19 rules with 100% confidence for single herbs and 2 rules for multi-herb combinations.Combining support degree，confidence，and Euclidean distance，the most valuable herb pairs for stroke are radix paeoniae alba，achyranthes bidentata，ochre as well as angelica，astragalus.Conclusion:In Yixue Zhongzhong Canxilu，the treatment of stroke emphasizes the use of herbs with neutral and cold properties，bitter and sweet tastes，and those associated with the liver and spleen meridians.In terms of drug dosage，although there are clear patterns for the use of keel & oyster，frankincense & myrrh，and achyranthes bidentata，other herbs show no significant dosage patterns.When treating stroke(cerebral congestion or hemorrhage)，radix paeoniae alba is first used to nourish liver blood for its soothing effect on the liver，and achyranthes bidentata is secondly used to the downward movement of qi and blood，followed by the application of ocher to firmly control and settle.Keel and oysters are often included for soothing the liver wood and gently calming the pulse.The use of concentrated rust water for decoction is a key feature.In the treatment of stroke(cerebral ischemia)，angelica and astragalus are initially used to balance yin and yang harnessing the mutual restraint of these forces and promoting the simultaneous generation of qi and blood.Frankincense and myrrh are ingeniously employed to regulate qi and open orifices，as well as to invigorate blood and resolve blood stasis.