Coronary heart disease(CHD) is a common clinical cardiovascular disease with many risk factors，high morbidity and mortality rates.CHD's symptoms are recurrent and seriously affect the physical and mental health of patients.The application of traditional Chinese medicine(TCM) can alleviate the symptoms and anxiety of patients with CHD through “double-heart treatment”.CHD belongs to the scope of “chest paralysis and heart pain” in TCM.Its complex pathogenesis involves various clinical syndromes，including heart meridian stasis syndrome，syndrome of blockade of phlegm-turbidity，qi stagnation chest syndrome，cold heart vein syndrome，phlegm-blood stasis syndrome，qi—yin deficiency syndrome，heart-kidney yin deficiency syndrome and heart-kidney yang deficiency syndrome.There are many therapeutic prescriptions specific for different types of symptoms，but the mechanism of action is still unclear.Proteomics technology is a technique for identifying proteins and studying protein characteristics，which can provide a comprehensive understanding of disease development.It can be used to explore diagnostic biomarkers，study protein differences in various TCM symptoms，and infer the mechanisms of TCM treatment for CHD.