Alzheimer's disease is the most common neurodegenerative disease，and its etiology and pathogenesis are still unclear.Currently，effective treatment drugs and methods are lacking.Microglia，as the innate immune cells of the central nervous system，play a central role in mediating neuroinflammation in the pathogenesis of Alzheimer's disease.Activation of autophagy can reduce neuronal apoptosis and inhibit neuroinflammation.Acupuncture has a significant therapeutic effect on Alzheimer's disease and has a regulatory effect on microglia，which can inhibit central inflammation，activate autophagy，and regulate synaptic plasticity.