Bone marrow mesenchymal stem cells(BMSCs) are adult stem cells with osteogenic differentiation ability.The weakening osteogenic differentiation ability of BMSCs can easily lead to a variety of bone-related diseases，such as osteoporosis.Based on the theory of traditional Chinese medicine that “kidney governs the bone and generates the marrow”，kidney-tonifying herbs are commonly used in the treatment of osteoporosis，which has the effect of regulating osteogenic differentiation of BMSCs.N6-methyladenosine(m6A) is a post-transcriptional modification of eukaryotic RNA and a key factor in osteogenic differentiation of BMSCs.This study explores the relationship between m6A dynamic modification and osteogenic differentiation of BMSCs，and analyzes the possible role and targets of kidney-tonifying herbs in regulating m6A modification，which can provide new targets for kidney-tonifying herbs in the treatment of osteoporosis，and provide ideas for the scientific interpretation of the theory of visceral manifestation of kidney in traditional Chinese medicine.