Based on the Traditional Chinese Medicine Inheritance Support System(v2.5) and data mining technology，this study explores the medication patterns traditional Chinese medicine(TCM) in the treatment of hyperemesis gravidarum based on modern clinical research literature，aiming to provide a theoretical evidence for clinical diagnosis and treatment.Methods:Clinical research documents were retrieved from Chinese database，and data were establish a database.The TCM inheritance support system(v2.5) was employed for frequency statistics，association rule analysis，cluster analysis of medication.Results:A total of 121 literatures were included in this study，incorporating 139 prescriptions involving 99 Chinese medicine herbs:The average frequency of usage was 12.22 times，and 22 herbs were used more than 13 times，with top 5 herbs being Rhizoma Pinelliae，Pericarpium Citri Reticulatae，Radix Glycyrrhizae，Caulis Bambusae in Taenia，Rhizoma Atractylodis; The order of four nature of herbs was warm，cold，mild，cool and hot; The order of five tastes was as follows:sweet，pungent，bitter，sour，astringent and salty; The sequence of meridians was as follows:spleen meridians，stomach meridians，lung meridians，heart meridians，kidney meridians，liver meridians，large intestine meridians，gallbladder meridians，small intestine meridians，and triple energizer meridians.Through association rule analysis，common drug pairs and drug combinations were identified，with the core drug combination being “Rhizoma Pinelliae-Pericarpium Citri Reticulatae-Radix Glycyrrhizae; Besides，A hierarchical cluster analysis of complex system entropy identified 16 potential core drug combinations(8 groups)，and further unsupervised entropy hierarchical cluster analysis revealed 8 potential new formula combinations.Conclusion:The high-frequency TCM herbs for treating hyperemesis gravidarum mainly focuses on tonifying deficiency，removing phlegm，regulating qi and removing dampness，and most of them have the functions of stopping vomiting，protecting gastric mucosa，regulating intestinal flora and gastrointestinal function.Core drug combinations and potential new prescriptions mostly work on strengthening spleen and invigorating qi，clearing heat-fire，dissipating phlegm for activating stagnancy，nourishing yin for promoting fluid production and preventing miscarriage.