To explore the therapeutic effect of Shugan Xiaoying Recipe combined with acupuncture application on thyroid nodules and the effects of this therapy on thyroid hormones，resistance index(RI)，pulsatility index(PI)，and microvascular density(MVD).Methods:Eighty patients with thyroid nodules treated at the Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University from January 2022 to June 2023 were selected and randomly allocated by the random number table method into a control group and an observation group，each comprising 40 patients.The control group received Western medical treatment，and the observation group was treated with Shugan Xiaoying Recipe combined with acupoint application on the basis of the therapy in the control group.The therapeutic effects were compared between the two groups in terms of thyroid hormones [free triiodothyronine(FT3)，free thyroxine(FT4)，and thyroid-stimulating hormone(TSH)] and ultrasound indicators(RI，PI，and MVD).Results:The response rate in the observation group was 92.50%，which was higher than that(75.00%) in the control group(P<0.05).The TCM symptom scores in the observation group were lower than those in the control group(P<0.05).The levels of FT4 and FT3 showed no significant differences between the two groups(P>0.05)，and the TSH level declined compared with that before treatment.Moreover，the observation group had more reduction in the TSH level than the control group after treatment(P<0.05).The treatment in both groups decreased the RI，PI，and MVD(P<0.05)，and the observation group exhibited lower RI，PI，and MVD than the control group after treatment(P<0.05).Conclusion:The combination of Shugan Xiaoying Recipe with acupoint application can alleviate TCM symptoms，lower the TSH level，and decrease RI，PI，and MVD in the patients with thyroid nodules，demonstrating definite therapeutic effects.