Real-world study(RWS) is a study that collects，processes，analyzes，and interprets real clinical medical data from multiple perspectives.Because its results have inherent validity and external generalizability，it is increasingly valued in the field of acupuncture and moxibustion.By analyzing the suitability of RWS for acupuncture and moxibustion clinical research on Autism Spectrum Disorder(ASD) in children，it is believed that RWS holds significant value in medical research on children with ASD.However，several potential problems in conducting RWS on acupuncture and moxibustion for children with ASD were identified：1) Lack of high-quality acupuncture and moxibustion clinical research evidence; 2) Absence of a clinical evaluation system; 3) Disconnect between clinical research outcomes and translation.In response to these problems，potential solutions for conducting RWS on acupuncture and moxibustion for children with ASD were discussed：1) Research scenarios，study duration，and sample size should be determined based on real data; 2) Due to broad inclusion and exclusion criteria，subjects had broad representativeness，and close monitoring of compliance was unnecessary; 3) Non-randomized interventions should be conducted based on the child's condition and parental preferences，with longer follow-up periods to observe individualized treatment outcomes; 4) RWS results should be analyzed reasonably from aspects such as baseline comparability，primary outcome indicators，and subgroup analysis; 5) Ethically，informed consent methods should be selected cautiously，risk-benefit considerations and privacy protection should be rigorously reviewed to better safeguard child ASD participants.Additionally，the future prospects of conducting RWS on acupuncture and moxibustion for children with ASD in real medical environments were outlined.