As a common target organ for distant metastasis in colorectal cancer，metastasis to the liver is influenced by various factors such as the immune system of the body and the tumor microenvironment.Liver metastasis is a major cause of death in patients with advanced colorectal cancer.Exosomes are extracellular vesicles with a diameter of 30 to 150 nm.Exosomes derived from colorectal cancer contain miRNAs and oncogenes that participate in tumor recurrence and metastasis.Traditional Chinese medicine(TCM) believes that the causes of colorectal cancer liver metastasis(CRLM) are mainly related to “deficiency of vital qi” and “excess of pathogenic qi”.TCM features holistic treatment，multiple components，and multiple targets，which can regulate intercellular communication through exosomes and affect the tumor microenvironment to prevent tumor recurrence and metastasis.On one hand，by “strengthening the vital qi，invigorating the spleen，and consolidating the foundation”，TCM can enhance the patient's immune system and improve the tumor-suppressive microenvironment.On the other hand，by “regulating qi，eliminating blood stasis，and removing toxin”，TCM can improve the tumor's inflammatory microenvironment，making it inhospitable for cancerous growth.