To observe the clinical effect of buccal acupuncture combined with paravertebral nerve block on post-herpetic neuralgia in the chest and back.Methods:A total of 100 patients with post-herpetic neuralgia treated in the Traditional Chinese Medicine Hospital of Wuxi from January to December in 2021 were randomized into an observation group(n=50) and a control group(n=50).The control group was treated with basic drugs combined with paravertebral nerve block，and the observation group was treated with buccal acupuncture on the basis of the therapy in the control group.The Visual Analogue Scale(VAS) scores before treatment and after treatment for 1，2，3，and 4 weeks were recorded.The 36-iterm Short-Form Health Survey(SF-36) score，serum level of neuron-specific enolase(NSE)，and Th1/Th2 level were determined before and after treatment.The incidence of adverse reactions and total response rate in the two groups were recorded and calculated.Results:The VAS scores in both groups declined after treatment，and the observation group had lower VAS score than the control group(P<0.05).The SF-36 score(except the item of physiological function) rose after treatment，and the observation group had higher SF-36 score than the control group(P<0.05).The NSE level reduced after treatment in both groups，and the reduction was more significant in the observation group than in the control group(P<0.05).After treatment，both groups showed elevated interferon-gamma(IFN-γ) level and lowered interleukin-4 and-10(IL-4 and IL-10) levels(P<0.05)，and the observation group had larger changes than the control group(P<0.05).Obvious adverse reactions occurred in neither group(P>0.05).The total response rate of the observation group was higher than that of the control group(P<0.05).Conclusion:Buccal acupuncture combined with paravertebral nerve block demonstrates a definite therapeutic effect on post-herpetic neuralgia in the chest and back.This therapy can relieve the pain，improve the quality of life during treatment，alleviate neuron damage，and enhance immunity of the patients.