To observe the clinical efficacy of ademetionine 1,4-butanedisulfonate combined with Ganshuang Granules in the treatment of patients with alcoholic liver disease and its effect on liver fibrosis markers.Methods:A total of 110 patients with alcoholic liver disease treated at the Hepatology Department of Affiliated Hospital of Shaanxi University of Chinese Medicine from July 2019 to June 2021 were enrolled and randomly divided into an observation group and a control group according to a random number table，with 55 patients in each group.The control group received basic therapy for alcoholic liver disease combined with Ganshuang Granules，which were taken with warm water，1 bag per dose，three times a day.The observation group received ademetionine 1,4-butanedisulfonate combined with Ganshuang Granules，with the same administration protocol of Ganshuang Granules as the control group，and an additional intravenous infusion of 1.0 g of ademetionine 1,4-butanedisulfonate and 250 mL of 0.9% sodium chloride injection，once daily.Both groups were treated for three courses，each course lasting one month.Liver function indicators[direct bilirubin(DBIL)，gamma-glutamyl transferase(GGT)，bile acid(BA)]，liver fibrosis indicators[proline dipeptidase(PLD)，type Ⅳ collagen(Ⅳ-C)，procollagen type Ⅰ N-terminal peptide(PINP)]，and inflammatory factors[interferon-induced protein-10(IP-10)，C-X-C motif chemokine ligand 1(CXCL1)，soluble vascular cell adhesion molecule-1(VCAM-1)] were measured before and after treatment.Adverse reactions of the two groups during treatment were recorded，and the total effective rate was calculated.Results:After treatment，the levels of DBIL，GGT，and BA in both groups were lower than those before treatment，and the levels in the observation group were significantly lower than those in the control group(P<0.05).The levels of PLD，Ⅳ-C，and PINP in both groups after treatment were also reduced compared to those before treatment，and the levels in the observation group were significantly lower than those in the control group(P<0.05).Similarly，the levels of IP-10，CXCL1，and VCAM-1 in both groups after treatment decreased compared to those before treatment，with the observation group showing significantly lower levels than the control group(P<0.05).The incidence of adverse reactions was 12.73%(7/55) in the observation group and 9.09%(5/55) in the control group，with no statistically significant difference(P>0.05).The total effective rate was 90.91%(50/55) in the observation group and 74.55%(41/55) in the control group，with the observation group showing a significantly higher total effective rate(P<0.05).Conclusion:Ademetionine 1,4-butanedisulfonate combined with Ganshuang Granules is highly effective in treating alcoholic liver disease，which can improve liver function and fibrosis markers and reduce inflammatory factor levels，demonstrating high safety.