To analyze the factors influencing disease-free survival in early-stage non-small cell lung cancer(NSCLC) patients after radical surgery and observe the impact of traditional Chinese medicine(TCM) intervention on these patients.Methods:A single-arm，single-center retrospective study was conducted on clinical data of 415 early-stage NSCLC patients who received TCM intervention.Kaplan-Meier method was used for univariate analysis of potential prognostic factors for early-stage NSCLC.Factors with significant results determined by significance testing were further analyzed using Cox regression to establish a Cox proportional hazards model.Results:The 1-year，2-year，3-year，5-year，and 10-year disease-free survival rates of 415 patients with early-stage NSCLC were 96.1%，87.5%，84.0%，76.5%，and 67.4%，respectively.Univariate analysis indicated that gender，age，smoking history，surgical method，pathological type，clinical stage，TCM syndrome differentiation，TCM medication and non-medication treatment duration，blank period of TCM intervention，and the duration of comprehensive TCM intervention were significant prognostic factors(P<0.05).Cox regression analysis identified gender，clinical stage，TCM syndrome differentiation，duration of Chinese patent medicine treatment，and duration of comprehensive TCM treatment as independent risk factors.Conclusion:TCM interventions could improve disease-free survival rates and prognosis in early-stage NSCLC patients.Among these patients，those who were female，younger，non-smokers，underwent video-assisted thoracoscopic surgery，had lung adenocarcinoma(predominantly lepidic subtype)，early clinical stage，and TCM syndromes of qi and yin deficiency or lung and spleen qi deficiency had better outcomes.A shorter TCM intervention blank period and prolonged comprehensive TCM treatment contributed to increased disease-free survival rates.