To explore the syndrome differentiation and medication characteristics of traditional Chinese medicine(TCM) masters in treating dampness syndrome.Methods:Data mining was conducted on dampness syndrome-related papers and medical cases through the Ancient and Modern Medical Record Cloud Platform V2.3.5 database，case database of famous doctor，CNKI，CSPD，and CBM to explore disease-syndrome-formula relationships.Results:A total of 358 articles，12 professional books，and 1 296 cases from the Ancient and Modern Medical Record Cloud Platform were included，amounting to 2 195 cases with dampness syndrome treated by 88 national TCM masters.These cases involved 84 Western medical diseases and 67 TCM diseases.The syndromes were classified into 15 types，including dampness-heat，dampness-turbidity，cold-dampness，combined phlegm，combined stasis，combined wind，combined toxin，and accompanying spleen deficiency or yin deficiency.Twenty-six frequently used Chinese herbal drugs were clustered into four groups，with network analysis revealing the core drug pair as Poria-Atractylodis Macrocephalae Rhizoma，and the core drug combination was Poria，Atractylodis Macrocephalae Rhizoma，Astragali Radix，Glycyrrhizae Radix et Rhizoma，Angelicae Sinensis Radix，Chuanxiong Rhizoma，Paeoniae Radix Alba，Coicis Semen，and Citri Reticulatae Pericarpium.Conclusion:The dampness syndrome cases treated by TCM masters often corresponded to Western diseases involving inflammation and autoimmune disorders.The core syndrome was dampness-heat，often accompanied by spleen deficiency，blood stasis，or kidney deficiency，reflecting complex pathogenesis.The treatment focused on strengthening the spleen and eliminating dampness，regulating qi，and invigorating blood，supplemented by drugs for clearing heat，removing toxins，resolving phlegm，and nourishing yin.