By integrating the traditional Chinese medicine(TCM) pathogenesis concept of healthy qi and pathogenic factors with the mechanisms of modern immunology，research on immune diseases has revealed that the core pathogenesis is the “struggle between the true qi and pathogenic forces”.“Healthy qi” represents the proper functioning of immune defense，immune surveillance，and immune homeostasis，while “pathogenic qi” refers to the pathological factors that induce immune dysfunction and the harmful pathological products formed as a result of abnormal immune functions.TCM approach of strengthening healthy qi to eliminate pathogens directly targets the “struggle between true qi and pathogenic forces”.It achieves immune regulation and stabilization by enhancing and/or suppressing immune functions，demonstrating effective results in the treatment of hypersensitivity reactions，autoimmune diseases，immunodeficiency disorders，infectious diseases，and tumors.