To evaluate the consistency in pharmacological quality between Dingban Mixture and Dingban Granules based on fingerprint and pharmacodynamic evaluation and to explore the mechanism of action of Dingban Qingre Formula.Methods:Fingerprint profiles of 12 batches of Dingban preparations were established to identify common peaks and their attributions，followed by data analysis and similarity evaluation.A dry yeast suspension was used to induce fever in rats，with medication administered for 7 days while recording body temperature.The antipyretic effects of aspirin，high-and low-dose Dingban Mixture，and high-and low-dose Dingban Granules were observed in febrile rats.A xylene-induced ear swelling model was also established in mice to assess the effects of aspirin，high-and low-dose Dingban Mixture，and high-and low-dose Dingban Granules on ear swelling.Enzyme-linked immunosorbent assay(ELISA) was used to measure levels of tumor necrosis factor-alpha(TNF-α) and interleukin-1 beta(IL-1β) in the hypothalamus of febrile rats.Results:The fingerprint analysis identified 13 common peaks across the 12 batches，demonstrating consistency between Dingban Mixture and Dingban Granules with the same material basis.Compared to the model group，both Dingban Mixture and Dingban Granules significantly reduced rectal temperature in febrile rats(P<0.05).The high-dose Dingban Granules group showed a significantly higher inhibition rate of ear swelling than the control group in the xylene-induced mouse model(P<0.05).Both Dingban Mixture and Dingban Granules inhibited the increase of TNF-α and IL-1β levels in the hypothalamus of febrile rats.Conclusion:Dingban Mixture and Dingban Granules exhibit consistency in fingerprint and pharmacological effects，both demonstrating antipyretic and anti-inflammatory actions.These effects may be mediated through the inhibition of TNF-α and IL-1β elevation in the hypothalamus of the model rats.