This study observed the application effect of Mailuoshutong Pills in patients after low anal fistula surgery.Methods:The study selected a total of 76 patients with low anal fistula admitted to the First Hospital of Harbin from January 2024 to April 2024.They all received surgery.The patients were grouped into the observation group(n=35) and control group(n=41) according to simple randomization grouping.The control group adopted the therapy of cutting with thread ligation，while the observation group orally took 4 g of Mailuoshutong Pills six hours after the therapy of cutting with thread ligation，three times per day for seven days.The visual analog scale(VAS)，procalcitonin(PCT)，and C-reactive protein(CRP)，hospital stays，recovery time，and curative effect of the two groups were recorded on the 1st，4th，and 7th days after the surgery.Results:On the 1st，4th，and 7th days after the surgery，VAS，serum PCT，and CPR levels in the observation group were lower than those in the control group(all P<0.05).The hospital stays and recovery time of the observation group were shorter than those of the control group(all P<0.05).In terms of clinical efficacy，the pain degree of the observation group was weaker than that of the control group，and the level of inflammation was lower than that of the control group.The hospital stays and average recovery time of the observation group were lower than those of the control group.Conclusion:The application of Mailuoshutong Pills in patients after low anal fistula surgery can reduce subjective pain，alleviate inflammatory responses，and shorter recovery time，with good high and tolerability.Mailuoshutong Pills have significant efficacy and high safety in promoting the rapid recovery of patients after low anal fistula surgery，which is worthy of further promotion in clinical practice.