类风湿关节炎中医证型及证素分布特征的文献研究概述
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国家自然科学基金青年科学基金项目(82305172);广东省基础与应用基础研究基金项目(2020B1515130005)


Overview of Literature Research on TCM Syndrome Type and Syndrome Element Distribution Characteristics of Rheumatoid Arthritis
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    摘要:

    目的:整理和归纳类风湿关节炎(RA)的中医证候及证候要素(证素)分布特征,了解其文献研究概况。方法:检索国家知识基础设施数据库、中文科技期刊数据库、中国生物医学文献数据库、中国学术期刊数据库、PubMed等电子数据库自2000年1月至2023年9月收录的RA中医证候研究文献,由2位研究者根据纳排标准独立完成文献筛选、文献信息整理,对年发文量、发文单位省份、资助基金、纳入患者信息、证候类型分布、证候要素分布及证素组合分布进行统计描述。结果:共纳入文献66篇,发文最多的单位所在省份为云南省(8篇),基金资助来源主要为国家级课题和省级课题。纳入文献包含病例总数32 365例,病例数最多的5种证型为风寒湿阻证(19.39%)、湿热痹阻证(16.36%)、寒湿痹阻证(10.64%)、痰瘀痹阻证(9.00%)、肝肾不足证(7.62%)。提取证素后获得RA病位证素3个,分别为肾、肝、脾;病性证素10个,其中频数最高的4种证素为湿19 284(30.16%)、寒13 663(21.37%)、热9 397(14.70%)、风8 945(13.99%)。证素组合形式以二证素和三证素组合形式居多,分别占62.91%和35.97%。结论:寒、热、湿、风为RA的重要病理因素,其病位集中于肾、脾、肝三脏,占比较大的证型及证候要素一定程度上解释了本病的病因病机。

    Abstract:

    This study aimed to summarize the traditional Chinese medicine(TCM) syndrome type and syndrome element distribution characteristics of rheumatoid arthritis(RA) and review the literature in this field.Methods:TCM syndrome-related literature on RA in China National Knowledge Infrastructure(CNKI),Chinese Citation Database(CCD),China Science Periodical Database(CSPD),China Biology Medicine Disc(CBM),and PubMed Database was collected from January 1st,2000 to September 30th,2023.Two researchers independently completed literature screening and literature information sorting according to the classification criteria and statistically described the annual number of publications,provinces of publishing units,funding funds,information of included patients,distribution of syndrome types,distribution of syndrome elements,and distribution of syndrome element combinations.Results:A total of 66 papers were included.The province with the most publications was Yunnan Province(n=8).The funding funds were mainly from national projects and provincial projects.The included articles included a total of 32 365 cases.The five syndrome types with the highest frequency were wind-cold-dampness obstruction(19.39%),damp-heat obstruction(16.36%),cold-dampness obstruction(10.64%),phlegm-stasis obstruction(9.00%),and deficiency of liver and kidney(7.62%).After the extraction of syndrome elements,three RA syndrome elements were obtained,which were kidney,liver,and spleen,and 10 pathogenic syndrome elements were obtained,among which the four syndrome elements with the highest frequency were dampness(n=19 284,30.16%),cold(n=13 663,21.37%),heat(n=9 397,14.70%),and wind(n=8 945,13.99%).The syndrome element combinations were mostly two-element and three-element combinations,accounting for 62.91% and 35.97%,respectively.Conclusion:The important pathological factors of RA are cold,heat,and dampness,and it is mainly located in the kidney,spleen,and liver.The major syndrome types and syndrome elements explain the etiology and pathogenesis of RA to a certain extent.

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伍嘉琪,李李,晏菁遥,何京谦,陈子枫,刘良,黄清春.类风湿关节炎中医证型及证素分布特征的文献研究概述[J].世界中医药,2024,(20).

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  • 收稿日期:2023-10-30
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  • 在线发布日期: 2025-01-16
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