中医药治疗肌少症的方法及其作用机制研究最新进展
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国家自然科学基金青年科学基金项目(82305275)——金匮肾气丸通过CREB/PGC-1a/Irisin通路介导肌骨交互干预脾肾阳虚型骨质疏松症的机制研究;国家中医药管理局王世轩全国名老中医药专家传承工作室建设项目(国中医药人教函〔2022〕75号);辽宁省科技厅博士科研启动基金计划项目(2023-BS-050)——基于“骨肉不相亲”理论探讨骨疏康调控Pi3k-Akt-Bad通路防治“肌少-骨质疏松症”的机制研究


Methods and Mechanisms of Traditional Chinese Medicine in the Treatment of Sarcopenia:A Review
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    摘要:

    肌肉减少症是一种老年疾病,其特征是骨骼肌质量逐渐丧失和肌肉功能丧失。目前我国的老龄化人口不断增加,肌少症相关的问题不断显现,肌肉减少症已成为临床研究的焦点。系统全面地探讨了中医药治疗肌肉减少症的方法及疗效,包括中药口服、针刺治疗、推拿疗法、中医功法锻炼等几方面,总结了各种疗法的优缺点及机制。认为中医对肌少症有着较为完整的理论认知及治疗方式,在治疗肌少症方面有独特优势。中药口服(单味中药或复方)是临床最常见、最便利的治疗方式,以补肾健脾为切入点,达到补肾阳,益脾气、滋养肌肉的作用,现代医学机制主要从调节肌生长抑素、抗衰老、控制炎症水平方面改善肌肉质量;针刺治疗肌少症的主要作用机制是提高神经肌肉传导速度,降低肌细胞凋亡,上调肌生长因子;推拿及功法直接作用于肌肉,有效提升骨骼肌质量、肌力水平及整体活动能力。

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    Sarcopenia is a condition commonly seen in the elderly,characterized by a gradual loss of skeletal muscle mass and muscle function.With the increasing aging population in China,problems related to sarcopenia have become increasingly prominent,making it a focal point for clinical research.This review systematically explored the methods and efficacy of traditional Chinese medicine(TCM) in treating sarcopenia,including oral administration of Chinese herbal medicine,acupuncture,tuina therapy,and TCM exercises,and summarized the advantages and disadvantages of various therapies and their mechanisms.It is believed that TCM offers a comprehensive theoretical understanding and treatment approaches for sarcopenia,providing unique advantages in its management.Oral administration of Chinese herbal medicine(whether single herbs or formulas) is the most common and convenient clinical treatment.It focuses on tonifying the kidneys and strengthening the spleen,thereby enhancing kidney yang,benefiting spleen qi,and nourishing muscles.Modern medicine mechanisms primarily improve muscle quality by regulating myostatin,combating aging,and controlling inflammation levels.The main mechanism of acupuncture in treating sarcopenia involves increasing neuromuscular conduction velocity,reducing muscle cell apoptosis,and upregulating muscle growth factors.Tuina and TCM exercises directly target muscles,effectively enhancing skeletal muscle quality,strength levels,and overall physical activity.

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魏巍,戚晓楠,谢鹏,于智同,王德羽,王世轩.中医药治疗肌少症的方法及其作用机制研究最新进展[J].世界中医药,2024,(20).

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  • 收稿日期:2023-08-04
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  • 在线发布日期: 2025-01-16
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