To explore the animal species,modeling methods,positive control drugs,and evaluation indicators used in animal models of non-alcoholic steatohepatitis(NASH),with the aim of providing a reference for basic research on NASH.Methods:A literature search was conducted using the keywords “non-alcoholic steatohepatitis”,“animal model”,“NASH”,“Nonalcoholic Steatohepatitis”,and “Animal Model” in the China National Knowledge Infrastructure(CNKI),Chinese Sci-tech Journal Database(CCD),China Academic Journal Database(CSPD),and PubMed databases.The types of experimental animals,sex,age,modeling methods,positive control drugs,and evaluation indicators were summarized and analyzed.Results:A total of 423 articles were included.The most commonly used animals in NASH models were male C57BL/6 mice and Sprague-Dawley(SD) rats.The most common modeling methods were high-fat diets and methionine-choline-deficient(MCD) diets.The modeling period was typically 56 or 84 days.The most frequently measured indicators were histopathological and serum biochemical markers,with hematoxylin-eosin(HE) staining being the most commonly used histological technique.Phosphatidylcholine was the most frequently used positive intervention drug.Conclusion:Although there are multiple methods for creating NASH animal models,limitations still exist.Therefore,data mining on NASH animal models can provide valuable insights and references for model selection and improvement.