Platinum-based chemotherapy regimens are the most important treatment methods for lung cancer，with significant clinical efficacy.However，resistance often develops in the later stages.Cisplatin(DDP) is the most commonly used non-cell cycle-specific cytotoxic chemotherapy drug for treating lung cancer，but resistance to DDP also occurs，limiting its clinical application.Currently，the mechanisms underlying DDP resistance in lung cancer are not fully understood，but they primarily include reduced intracellular drug concentration，abnormal DNA damage repair ability，activation of protective autophagy，inhibition of apoptosis，regulation of ferroptosis，and other resistance mechanisms.Various natural compounds have been shown to reverse DDP resistance in lung cancer，making them important sources for the development of new anticancer drugs.