The incidence of brain function-related diseases has been increasing annually,and actively protecting and enhancing brain health has become a major challenge for human health.Professor GUO Yi,based on the wisdom of traditional Chinese culture,classic traditional Chinese medicine(TCM) theory,modern science,and over 30 years of research by his team,has found that stimulating the Well acupoints has significant benefits for brain health.He proposed the academic concepts of “Well acupoint stimulation for brain health enhancement” and “Well acupoint-brain(heart) correlation”.By exploring ancient and modern literature on Well acupoints,this study examines both the theoretical and practical aspects of the brain-enhancing and brain-protecting effects of Well acupoint stimulation,including its theoretical basis,mechanisms of action,and clinical efficacy.This study is expected to provide a theoretical foundation for Well acupoint interventions in the diagnosis,prevention,treatment,and healthcare of brain function-related diseases,and to promote the broader clinical application of Well acupoint therapy.