To explore the changes in serum liver function indicators,virological markers,liver fibrosis indicators,inflammatory mediators and chemokines,cellular immune indicators,and certain blood routine parameters in chronic hepatitis B(CHB) patients with dampness-heat syndrome(DHS) based on DHS syndrome score.Methods:A retrospective analysis was conducted using clinical data from 36 healthy volunteers and 148 CHB patients treated at Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Ningbo No.2 Hospital,Shaoxing Sixth People's Hospital,The Second Hospital of Nanjing,and Huai'an No.4 People's Hospital between November 2009 and May 2014.Clinical Guiding Principles for New Chinese Medicines(2002 edition) was used to determine the primary and secondary symptoms of liver-gallbladder DHS and to calculate syndrome scores.Patients were divided into a typical DHS group(40 cases) and a non-typical DHS group(108 cases),based on their syndrome scores and whether their tongue coating was yellow and greasy.The differences in serum liver function,virological markers,liver fibrosis markers,inflammatory mediators and chemokines,cellular immune markers,and some blood routine parameters were compared between the two groups.Results:Compared to the non-typical DHS group,the typical DHS group showed significantly higher serum levels of glutamic oxalacetic transaminase(GOT),alkaline phosphatase(ALP),and aspartate aminotransferase to platelet ratio index(APRI),as well as higher percentages of monocytes and mononuclear cells.The expression of inflammatory cytokines,including interleukin-6(IL-6),IL-8,IL-16,macrophage migration inhibitory factor(MIF),monocyte chemoattractant protein-1(MCP-1/CCL2),and hepatocyte growth factor(HGF),were also significantly increased(P<0.05).Conclusion:Patients with typical DHS in CHB exhibit elevated clinical manifestations,including higher levels of liver function indicators,liver fibrosis markers,immune markers,and inflammatory mediators and chemokines,suggesting associated liver injury.