Dampness is an important pathological product and mechanism in the development of chronic kidney disease(CKD).The removal of dampness and the promotion of qi transformation are key therapeutic strategies in traditional Chinese medicine(TCM).However,there has been limited research focusing on the essence of dampness in CKD.This article,based on the brain-gut-kidney axis theory,expands the understanding of the generation and pathogenic mechanisms of dampness in CKD.It provides a new perspective on the prevalence,complexity,and difficulty of treating dampness in CKD,offering fresh insights for clinical treatment.