Acupuncture manipulation is key to the therapeutic effect of acupuncture and serves as an important entry point for revealing the principles and mechanisms of acupuncture.With the continuous evolution of the field of acupuncture,research on acupuncture manipulation is gradually shifting towards exploring “why” acupuncture treats diseases and “how to better” treat diseases.Driven by the concept of computational acupuncture,research on acupuncture manipulation,with data as a core element,is increasingly oriented towards clinical application,mechanism of action,characterization and quantification,as well as the informatization,networking,digitalization,and intelligence of simulation and evaluation.Although computational acupuncture is still in its early stages,the new ideas and methods it contains are expected to enhance the depth and breadth of acupuncture manipulation research,which have significant implications for the overall development of acupuncture.