The prevalence of gout has been rising year by year，but its pathogenesis is complex，and there is a lack of effective therapeutic drugs in clinical practice.Traditional Chinese medicine(TCM) has been proven to be effective in treating gout，with its pathogenesis categorized under the “dampness-heat-cold-stasis-deficiency” network.This article elaborates on the connotation of the complex pathogenesis network of “dampness-heat-cold-stasis-deficiency” from the perspective of TCM，and combines the biological basis of modern medicine，including intestinal flora imbalance，inflammatory response，oxidative stress，microcirculation disorders，and immune dysfunction，to provide a reference for TCM syndrome differentiation，treatment，and prevention of gout.This also contributes to the development of TCM and the refinement of its modern connotations.