“药辅合一”特性天然中药凝胶治疗糖尿病创面的研究进展
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国家自然科学基金委-广东联合基金联合集成项目(U23A6012);国防科技创新特区H863计划项目(20-163-02-ZT-008-003-01);中央高校基本科研业务费专项基金资助项目(2023-JYB-XJSJJ-013);北京中医药大学大学生创新创业训练计划项目(90012962420061,90012962420031,s202310026032,X202310026158,X202310026070)


Natural Chinese Medicine Hydrogels in the Treatment of Diabetic Wound Based on the Theory of “Drug-excipient Unification”
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    摘要:

    糖尿病创面愈合延迟,治疗周期长,传统清创换药难以满足临床需求。“药辅合一”特性天然中药具有“药效物质”与“成胶辅料”的特点,其水凝胶有保水、保护伤口、负载药物实现缓释等效果,为伤口提供湿性愈合环境,通过抗菌、抗炎、抗氧化、促进血管生成等多种作用途径促进伤口愈合。本文对具有“药辅合一”特性的中药水凝胶的设计及促进糖尿病创面愈合的效果进行系统梳理,从而为中药材的新剂型开发和应用提供参考。

    Abstract:

    Diabetic wound healing is delayed,with long treatment cycles,and traditional debridement and dressing changes often fail to meet clinical needs.Natural Chinese medicines characterized by “drug-excipient unification”,which combine both “active pharmaceutical substances” and “gel-forming excipients”,offer promising solutions.Chinese medicine hydrogels,with their water-retention properties,wound protection,and drug delivery capabilities for sustained release,provide a moist healing environment.They promote wound healing through various mechanisms,including antibacterial,anti-inflammatory,antioxidant actions,and stimulation of angiogenesis.This article systematically reviews the design of Chinese medicine hydrogels with “drug-excipient unification” characteristics and its effects in promoting diabetic wound healing,offering insights for the development and application of new dosage forms of Chinese medicinal herbs.

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耿少辉,刘丽,兰馨怡,高瑜若,刘怡柯,黄光瑞.“药辅合一”特性天然中药凝胶治疗糖尿病创面的研究进展[J].世界中医药,2025,(01).

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  • 收稿日期:2024-01-06
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  • 在线发布日期: 2025-03-30
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