Non-small cell lung cancer(NSCLC) is the main pathological type of primary lung cancer，accounting for approximately 85% of lung cancer cases.Lung cancer ranks second in terms of incidence among all malignant tumors.Most patients are diagnosed at an advanced stage，missing the optimal opportunity for surgery.The damage caused by chemotherapy and radiation therapy leads to poor patient adherence，often resulting in unsatisfactory outcomes.Traditional Chinese medicine(TCM) has multi-pathway，multi-target effects，and can reduce the damage caused by chemotherapy and radiation，improving the patient's quality of life and extending survival，offering hope for patients with advanced lung cancer.Research has shown that lung cancer is regulated by numerous signaling pathways，with the Janus kinase(JAK)/signal transducer and activator of transcription protein(STAT) pathway being one of the key regulatory pathways.The JAK/STAT pathway affects lung cancer cell proliferation，invasion，and metastasis by regulating the cell cycle，inhibiting apoptosis，and promoting angiogenesis.Literature reviews have found that both TCM formulas and single compounds play an indispensable role in the proliferation，metastasis，and apoptosis of NSCLC cells through the JAK/STAT signaling pathway.Increasing animal studies are exploring the mechanisms by which TCM influences lung cancer through the JAK/STAT pathway.