The four major Huai medicines have a long history of use，proven therapeutic efficacy，and are important medicinal and edible plants in China，widely applied in various fields with a broad market demand.In the process of production and application，many non-medicinal parts of these medicines are often neglected or discarded，resulting in significant resource waste.The development and utilization of non-medicinal parts of Chinese medicinal materials have become a current research hotspot.Studies have shown that different parts of the same medicinal plant often contain the same or similar chemical components and physiological activities，with some chemical constituents in non-medicinal parts even being present in higher concentrations than in the medicinal parts.This review，based on publicly published literature，summarizes and analyzes the functional indications，historical and modern medicinal uses，chemical components，pharmacological effects，and resource utilization approaches of the non-medicinal parts of the four major Huai medicines，aiming to increase the utilization rate of medicinal resources，promote the development of the Chinese medicine industry，enhance the ecological functions of Chinese medicine ecological agriculture，and provide insights and reference for boosting economic development through ecological functions.Most non-medicinal parts have a long history of use，are rich in chemical components，and exhibit significant pharmacological effects，making them applicable in industries such as food，pharmaceuticals，health products，animal husbandry，and chemicals.In the future，rational development and utilization of non-medicinal parts of the four major Huai medicines can be explored in areas such as quality management，basic theoretical research，and product development.