To systematically review the clinical features of pulmonary nodule patients with a focus on symptoms，syndrome elements，syndromes，and constitution characteristics that are distinct in traditional Chinese medicine(TCM)，based on cross-sectional studies.Methods:A computer-based literature search was conducted in both Chinese and English databases for cross-sectional studies on symptoms(including physical symptoms and emotional states)，syndrome elements，syndromes，and constitution in pulmonary nodule patients.Databases searched included China National Knowledge Infrastructure(CNKI)，China Science Periodical Database(CSPD)，Chinese Citation Database(CCD)，China Biology Medicine disc(CBM)，PubMed，Embase，and Web of Science，covering articles published from the inception of these databases until January 7，2024.The quality of the included studies was evaluated using the JBI Critical Appraisal Checklist for Studies Reporting Prevalence Data.A systematic review approach was employed to analyze the included literature.Results:A total of 76 studies were included，covering 20 provinces in China and three countries(the United States，the United Kingdom，and Sweden)，with a total sample size of 26 284 patients.The overall methodological quality of the included studies was moderate，with areas such as sample size，sampling methods，and inclusion/exclusion criteria needing improvement.The studies indicated that，in addition to respiratory symptoms like cough，expectoration，chest tightness，and chest pain，common systemic symptoms in pulmonary nodule patients included sleep disturbances，fatigue，and anxiety/depression.The main syndrome elements were related to the lungs，spleen，and liver，with pathological elements such as phlegm，dampness，stasis，heat，qi deficiency，and yin deficiency being prevalent.The primary syndromes included phlegm-dampness obstruction of the lungs，stasis in the lung collaterals，liver depression and qi stagnation，and spleen deficiency with phlegm-dampness.Common constitution types included qi deficiency，qi stagnation，and phlegm-dampness constitution.Conclusion:The existing literature on the clinical features of pulmonary nodule patients，including symptoms，syndrome elements，syndromes，and constitution，shows significant variability in the standards for evaluation.The methodological quality and evidence value of the studies are limited.