To construct a predictive model for high-risk pulmonary nodules，providing a basis for the risk stratification management of pulmonary nodules.Methods:A total of 460 patients with non-high-risk pulmonary nodules detected by CT between June 2022 and December 2023 at the Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine were selected.Traditional Chinese medicine(TCM) information was collected at the time of inclusion and followed up with CT reexamination 6 months to 1 year later.Factors influencing progression in the progression group and stable group were observed，and a predictive model for nodule progression was established.Results:Among the 460 patients，22 were in the progression group and 438 in the stable group.The predictive model for the progression of nodules to high-risk status was Logit(P)=-5.992+2.113*(elderly group)+1.430*(lung syndrome)+1.674*(yang deficiency syndrome)+1.871*(heat syndrome)+2.127*(partially solid nodules)+1.941*(family history of cancer)+1.609*(diabetes).Conclusion:The potential influencing factors for the progression of non-high-risk pulmonary nodules to high-risk status include elderly age，family history of cancer，diabetes，partially solid nodules，lung syndrome，yang deficiency syndrome，and heat syndrome.These factors can serve as a clinical basis for determining whether a nodule progresses.