Gallbladder stones are a major risk factor for gallbladder cancer，with an increasing incidence due to improved living standards and aging populations.They are often accompanied by acute and chronic cholecystitis.Currently，laparoscopic cholecystectomy is the primary clinical treatment.However，it remains controversial and carries a risk of postoperative recurrence.Establishing an ideal animal model that closely aligns with the clinical characteristics of gallbladder stones in both traditional Chinese medicine(TCM) and Western medicine is crucial for understanding its etiology and pathogenesis，as well as for improving clinical diagnosis and treatment.This study systematically searched and analyzed literature on gallbladder stone-related animal experiments from databases such as CNKI，Wanfang Data，VIP，and PubMed，summarized the commonly used animal species and modeling methods for gallbladder stones worldwide，and assessed advantages，limitations，and alignment of clinical symptoms with TCM syndromes of each model based on the diagnostic criteria of Western medicine and TCM，aiming to provide a reference for selecting and applying animal models in gallbladder stone research.