The incidence of colorectal cancer(CRC) is increasing annually，posing a significant global public health challenge.Baicalin，a major active compound of Scutellariae Radix，has gained attention for its unique anticancer properties.Studies have shown that baicalin inhibits the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)，Hedgehog，and Wnt signaling pathways，upregulates pro-apoptotic proteins p53 and RIP3，and suppresses cancer cell proliferation.Additionally，baicalin induces apoptosis in colorectal cancer cells，regulates the caspase family proteins，and arrests the cell cycle.It also reduces cancer cell invasion and migration by inhibiting epithelial-mesenchymal transition(EMT) and downregulating matrix metalloproteinase-9(MMP-9) and cyclooxygenase-2(COX-2).Moreover，baicalin has the potential to induce autophagy，reverse drug resistance，and mitigate inflammatory responses and inflammation-cancer transformation risks.