Cardiovascular and cerebrovascular diseases are complex in etiology and pathogenesis，posing significant threats to human health.In recent years，extensive studies have reported that inflammation plays a crucial role in the onset and progression of these diseases，and targeting the α7 nicotinic acetylcholine receptor(α7nAChR) to counteract inflammation has emerged as a novel therapeutic approach.Researchers have explored the role of α7nAChR in cardiovascular and cerebrovascular diseases and its underlying molecular mechanisms through interventions such as vagus nerve stimulation and pharmacological activation.However，these methods face various limitations in clinical applications.Acupuncture，a traditional Chinese medicine(TCM) therapy with a history spanning thousands of years，has been demonstrated to activate α7nAChR by stimulating the vagus nerve，exerting effects similar to those of pharmacological non-acupuncture therapies.Nevertheless，the molecular mechanisms underlying acupuncture's activation of α7nAChR in cardiovascular and cerebrovascular diseases remain inadequately understood，hindering its therapeutic optimization.