To optimize the extraction process of Chinese medicine compound formulas using both central composite design-response surface methodology(CCD-RSM) and orthogonal design，in combination with the analytic hierarchy process-entropy weight method(AHP-EWM)，and to provide a reference for selecting optimal Chinese medicine extraction methodologies.Methods:The comprehensive score，based on the transfer rates of puerarin，hesperidin，and liquiritin，as well as the extract yield，was used as the response value.Water-to-material ratio，extraction time，and number of extractions were selected as key process parameters.The AHP-EWM was applied to determine the weight coefficients of each evaluation index and calculate the comprehensive score.Both CCD-RSM and orthogonal design were used to optimize the extraction parameters，followed by experimental validation and comparison.Results:Using the extraction process of Shenling Chewable Tablets as a case study，the optimal extraction conditions obtained by the orthogonal design and the response surface methodology were different.However，in both methods，the relative standard deviations(RSD) of three validation batches were all below 3.0%，and the comprehensive scores closely matched the predicted values from each respective design.Conclusion:The response surface methodology offers more refined process optimization with good reproducibility and operability，making it more suitable than the orthogonal design for practical production of Shenling Chewable Tablets.