Skeletal muscle injury is a common condition characterized by muscle cell damage due to mechanical trauma or other factors，triggering localized inflammatory responses.Typical symptoms include pain，swelling，and impaired motor function.As a frequent clinical concern，skeletal muscle injuries are associated with various diseases and may lead to muscle fibrosis and functional impairment，significantly reducing patients' quality of life.Tuina has shown remarkable efficacy in skeletal muscle injury rehabilitation.Compared with other treatments，Tuina is associated with fewer adverse reactions，making it more acceptable to patients.Recent studies suggest that skeletal muscle repair depends not only on intrinsic regenerative capacity of the muscle but also on the regeneration of surrounding vascular networks.Furthermore，nerve reinnervation plays a crucial role in restoring skeletal muscle structure and function.The coordinated regeneration of the vascular-nerve network is thus essential for skeletal muscle regeneration.This study explores the application mechanisms of Tuina therapy in skeletal muscle injury treatment from multiple aspects based on vascular-nerve network regeneration，aiming to provide insights for basic research on Tuina's role in skeletal muscle repair and offer new strategies for clinical prevention and treatment of skeletal muscle injuries，promoting both structural and functional recovery.