Autism spectrum disorder(ASD) has become one of the major challenges in the field of neurodevelopmental disorders globally，with its incidence ranking first among various mental health conditions in China.Children with ASD commonly exhibit gastrointestinal symptoms and gut microbiota imbalances，which are closely related to the severity of their behavioral and psychological disorders.The gut microbiota，through the gut-brain axis，interacts with mental health diseases，and regulating the gut microbiome could be a key target for the prevention and treatment of ASD.Pediatric Tuina，a traditional Chinese medicine(TCM) therapy，has shown significant effects in improving gastrointestinal microbial imbalances in children and has also demonstrated remarkable therapeutic outcomes for mental and neurological disorders.Based on existing research，this article explores the potential of pediatric Tuina in treating ASD through the mechanism of “treating the brain via the gut” by regulating gastrointestinal function，providing theoretical support for Tuina therapy as an intervention for ASD.