To analyze differences in anxiety and depression among type 2 diabetes mellitus(T2DM) patients with different constitutions and syndromes.Methods:Data were collected from 202 outpatients and inpatients with T2DM at Nephrology and Endocrinology Department of Dongzhimen Hospital between January 2022 and February 2023.Statistical analysis was conducted on patient constitution，syndrome，Hamilton Anxiety Rating Scale(HAMA) scores，and Hamilton Depression Rating Scale(HAMD) scores.Results:Postprandial 2-hour blood glucose was correlated with HAMD scores，and a regression equation was established：Standardized HAMD score=standardized postprandial 2-hour blood glucose × 0.14.The six constitution types(three yin types and three yang types) showed significant correlations with HAMA and HAMD scores(P<0.05)，with differences observed among different constitutional types(P<0.05).Patients with a Shaoyang constitution exhibited higher HAMA and HAMD scores than other types(P<0.05)，whereas those with a Taiyang constitution had lower scores(P<0.05).Similarly，TCM syndromes were correlated with HAMA and HAMD scores(P<0.05)，with significant differences in HAMA scores among different syndromes(P<0.05).Qi deficiency syndrome was associated with higher HAMA scores than other syndromes(P<0.05)，while depressive heat syndrome was associated with lower HAMA scores(P<0.05).Conclusion:Anxiety and depression levels vary among T2DM patients with different constitutions and syndromes.Patients with a Shaoyang constitution tend to have higher HAMA and HAMD scores，while those with qi deficiency syndrome exhibit higher HAMA scores.