With a refined formula and appropriate combination，Sini San，a commonly used classical formula，has the effects of regulating qi movement and resolving stagnated yang.In this paper，the literature of nearly 20 years was collated to summarize the application of Sini San in digestive system tumors from the perspectives of evidence exploration，clinical application，and mechanism research.It is found that this formula has the characteristics of regulating and harmonizing the Middle Earth，dredging the liver and nourishing the wood，as well as regulating the qi movement.In terms of clinical application，Sini San has the following functions. 1)Treating pre-cancerous lesions in the digestive system，reversing the malignant tumor evolution. 2)Directly treating digestive system tumors. 3)Alleviating cancer pain，depression，insomnia，and other common complications of tumors. 4)Alleviating the adverse reactions of digestive system tumors due to Western medical treatments，including the surgery side effects，and adverse reactions of chemotherapies and targeted therapies，to improve life quality.In mechanism research，Sini San has the effect of improving cell damage，reducing inflammation，inhibiting tumor cell proliferation，promoting tumor cell apoptosis，anti-angiogenesis，and inhibiting tumor metastasis.In both clinical and mechanistic research，the treatment of digestive system tumors with Sini San is in line with the traditional Chinese medicine(TCM) theory of “preventive treatment of disease”.Through literature search and summarization，this paper systematically reviews the current research status of Sini San in digestive system tumors，and summarizes the shortcomings of the current clinical research and experimental mechanism research，with a view to providing theoretical support and new ideas for the subsequent in-depth research on the prevention and treatment of tumor by classical prescription